Heinz Wiendl Selected Research

Ligands

11/2019	Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis.
1/2017	Liver X receptor activation promotes differentiation of regulatory T cells.
1/2017	Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G.
1/2016	CD4+ T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients.
12/2015	The NKG2D-IL-15 signaling pathway contributes to T-cell mediated pathology in inflammatory myopathies.
12/2011	Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.
7/2006	Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro.
1/2002	Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials.

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Heinz Wiendl Research Topics

Disease

169	Multiple Sclerosis 05/2024 - 01/2002
45	Relapsing-Remitting Multiple Sclerosis 05/2024 - 10/2008
36	Inflammation (Inflammations) 03/2024 - 11/2003
22	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 11/2022 - 11/2003
19	Neoplasms (Cancer) 03/2022 - 05/2002
17	Progressive Multifocal Leukoencephalopathy 04/2023 - 02/2011
16	Myasthenia Gravis 05/2024 - 01/2019
16	Infections 05/2024 - 04/2011
16	Neuroinflammatory Diseases 01/2023 - 07/2007
15	Disease Progression 03/2024 - 09/2008
13	Autoimmune Diseases (Autoimmune Disease) 12/2022 - 11/2008
11	Glioma (Gliomas) 01/2023 - 05/2002
11	Myositis (Idiopathic Inflammatory Myopathies) 01/2022 - 05/2003
9	Demyelinating Diseases (Demyelinating Disease) 01/2023 - 11/2003
7	COVID-19 02/2023 - 01/2020
7	Neuromyelitis Optica (Devic's Disease) 01/2023 - 01/2015
7	Ischemic Stroke 01/2023 - 06/2014
7	Deglutition Disorders (Dysphagia) 01/2022 - 01/2019
7	Rheumatoid Arthritis 01/2018 - 08/2007
7	Encephalitis (Encephalitis, Rasmussen) 04/2016 - 07/2006
6	Cognitive Dysfunction 04/2024 - 01/2017
6	Limbic Encephalitis (Paraneoplastic Limbic Encephalitis) 03/2024 - 01/2015
6	Stroke (Strokes) 01/2020 - 01/2009
6	Central Nervous System Diseases (CNS Diseases) 01/2017 - 09/2009
6	Rhabdomyosarcoma 11/2008 - 07/2002
5	Atrophy 10/2023 - 07/2012
5	Autoimmune Diseases of the Nervous System 01/2023 - 04/2016
5	Polymyositis 12/2015 - 07/2002
4	Epilepsy (Aura) 04/2024 - 11/2019
4	Alzheimer Disease (Alzheimer's Disease) 01/2024 - 11/2005
4	Chronic Progressive Multiple Sclerosis 11/2023 - 11/2005
4	Brain Diseases (Brain Disorder) 01/2022 - 06/2015
4	Primary angiitis of the central nervous system 01/2021 - 01/2018
4	Infarction (Infarctions) 01/2020 - 01/2009
3	Seizures (Absence Seizure) 04/2024 - 10/2021
3	Dementia (Dementias) 01/2024 - 01/2015
3	Body Weight (Weight, Body) 10/2023 - 11/2003
3	Ganglion Cysts (Ganglion) 01/2023 - 10/2018
3	Muscle Weakness 01/2023 - 05/2021
3	Autoimmune limbic encephalitis 01/2023 - 12/2021
3	Encephalomyelitis (Myeloencephalitis) 11/2022 - 07/2014

Drug/Important Bio-Agent (IBA)

38	Natalizumab (Tysabri)FDA Link 04/2023 - 06/2007
29	AntibodiesIBA 05/2024 - 11/2003
26	Alemtuzumab (Campath)FDA Link 01/2023 - 01/2012
25	Proteins (Proteins, Gene)FDA Link 05/2024 - 07/2002
19	Monoclonal AntibodiesIBA 01/2024 - 01/2002
19	AntigensIBA 01/2023 - 01/2002
17	Biomarkers (Surrogate Marker)IBA 11/2023 - 09/2013
16	Cladribine FDA LinkGeneric 02/2023 - 01/2002
15	CytokinesIBA 12/2018 - 01/2002
15	HLA-G Antigens (HLA G)IBA 01/2017 - 05/2002
12	Fingolimod Hydrochloride (FTY720)FDA Link 09/2023 - 06/2012
12	Myelin-Oligodendrocyte GlycoproteinIBA 01/2023 - 11/2003
11	AutoantibodiesIBA 01/2023 - 01/2017
10	TabletsIBA 02/2023 - 10/2017
10	Potassium Channels (Potassium Channel)IBA 07/2015 - 05/2008
9	Cholinergic ReceptorsIBA 02/2024 - 01/2019
9	teriflunomideIBA 10/2023 - 03/2014
9	Messenger RNA (mRNA)IBA 05/2022 - 05/2002
9	Rituximab (Mabthera)FDA Link 01/2022 - 01/2008
8	Immunoglobulin G (IgG)IBA 01/2023 - 01/2019
8	LigandsIBA 11/2019 - 01/2002
7	Interferon-betaIBA 01/2023 - 10/2004
6	Immunoglobulins (Immunoglobulin)IBA 01/2024 - 01/2018
6	VaccinesIBA 02/2023 - 01/2021
6	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 01/2023 - 04/2016
6	Integrin alpha4beta1 (VLA-4)IBA 11/2022 - 06/2007
6	Dimethyl FumarateIBA 02/2022 - 02/2016
6	HLA-DR Antigens (HLA-DR)IBA 01/2021 - 05/2003
6	Transcription Factors (Transcription Factor)IBA 01/2021 - 10/2006
5	InterferonsIBA 03/2024 - 04/2016
5	glucose-mannose-glucoseIBA 02/2024 - 01/2021
5	Retinaldehyde (Retinal)IBA 01/2024 - 04/2016
5	ofatumumab FDA Link 10/2023 - 01/2020
5	Protein Isoforms (Isoforms)IBA 01/2023 - 01/2015
4	EnzymesIBA 05/2024 - 01/2015
4	N,N- diethyl- 2- (2- (4- (2- fluoroethoxy)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamideIBA 03/2024 - 01/2020
4	Vitamin D FDA LinkGeneric 01/2023 - 03/2014
4	HLA Antigens (Human Leukocyte Antigens)IBA 01/2023 - 01/2018
4	Neuroprotective AgentsIBA 11/2022 - 01/2018
4	T-Cell Antigen Receptors (T-Cell Receptor)IBA 11/2022 - 01/2002
4	eculizumab FDA Link 01/2022 - 01/2020
4	ocrelizumabIBA 01/2022 - 01/2021
4	Interferon beta-1a FDA Link 12/2021 - 10/2015
4	Intravenous Immunoglobulins (IVIG)FDA Link 08/2021 - 01/2002
4	Daclizumab (Zenapax)FDA Link 01/2019 - 07/2013
4	IntegrinsIBA 01/2019 - 06/2014
4	Glatiramer Acetate (Copaxone)FDA Link 04/2016 - 01/2012
4	Peptides (Polypeptides)IBA 07/2014 - 01/2002
3	CalciumIBA 05/2024 - 05/2013
3	Agammaglobulinaemia Tyrosine KinaseIBA 03/2024 - 01/2023
3	Immunosuppressive Agents (Immunosuppressants)IBA 01/2023 - 01/2002
3	Complement System Proteins (Complement)IBA 01/2023 - 06/2013
3	Leucine (L-Leucine)FDA Link 01/2023 - 04/2016
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2023 - 04/2016
3	RNA (Ribonucleic Acid)IBA 01/2023 - 12/2011

Therapy/Procedure

85	Therapeutics 04/2024 - 01/2002
15	Immunotherapy 01/2023 - 12/2008
5	Activities of Daily Living (ADL) 02/2024 - 01/2022
3	Thrombectomy 01/2023 - 01/2020